Herxheimer reaction, also known as a Herx reaction, is a temporary immune system response that occurs after treatment for certain infectious diseases, particularly those caused by bacteria or parasites. It is named after dermatologists Adolf Jarisch and Karl Herxheimer, who independently described the phenomenon.

The Herx reaction usually occurs when a large number of pathogens are killed off rapidly by antibiotic or antimicrobial therapy, leading to the release of endotoxins or other harmful substances from the dying microorganisms. These released toxins can trigger an exaggerated immune response in the body, resulting in a range of symptoms.

Common symptoms associated with a Herx reaction include:

1. Flu-like symptoms. Patients may experience: fever, chills, sweating, headache, muscle aches, and fatigue resembling the symptoms of the flu.

2. Worsening of existing symptoms. If the infection being treated was causing specific symptoms, such as rash, joint pain, or neurological symptoms, those symptoms may temporarily increase before improving.

3. Inflammation. Inflammatory reactions like: joint swelling, increased pain, or skin redness may occur.

4. Gastrointestinal symptoms. Nausea, vomiting, diarrhea, and abdominal pain may be present.

5. Skin manifestations. Rashes, itching, and increased skin sensitivity may develop.

The duration and severity of the Herx reaction vary depending on several factors, including: the type and extent of the infection, the aggressiveness of the treatment, and the overall health of the individual. Typically, the reaction starts within a few hours to days after initiating treatment and lasts for a few days, although it can persist for a couple of weeks in some cases.

If you experience a Herx reaction, reduce your dosage of your tincture until the symptoms are gone. 

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Herxheimer Reaction Handout